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 Until the 1990s, the widespread use of chlorofluorocarbons (CFCs) for refrigerants and aerosols created an ozone hole in the Earth's stratosphere (the second layer of the atmosphere from Earth's surface) over Antarctica. CFCs deplete ozone, because they can bind to oxygen molecules in several chemical reactions, breaking ozone down into regular oxygen molecules. Without the ozone there, harmful UV rays can reach the planet's surface, posing a threat to humans and Earth's other life forms.